Linn, A. J., Van Weert, J. C. M., Smit, E. G, Perry, K., & Van Dijk, L. (2013). 1+1=3? The systematic development of a theoretical and evidence-based tailored multimedia intervention to improve medication adherence. Patient Education and Counseling. 93, 381-388. doi:10.1016/j.pec.2013.03.009

Abstract:
Objective:
To describe the development of a theoretical and evidence-based tailored multimedia intervention to improve medication intake behavior in patients with inflammatory bowel disease (IBD). The intervention integrates interpersonal and technology-mediated strategies with the expectation that this will work synergistically.
Methods: The development followed the Medical Research Council’s framework. Three literature reviews and three pre-tests among 84 IBD patients and eight nurses were conducted to guide the development of the intervention. A feasibility study was carried out among four nurses and 29 patients.
Results: The components include: (1) an online preparatory assessment (OPA); (2) tailored interpersonal communication; and (3) tailored text messaging. To support the development, the feasibility was tested. Results indicated that the OPA was comprehensive and could be a helpful tool for both patients and nurses to prepare for the consultation. The training was evaluated as being instructive and applicable with a mean mark of 8.5. Of the developed messages, 65.6% received positive evaluations and were used in the intervention.
Conclusion: By applying the framework, we were able to describe the logic behind the development of a tailored multimedia intervention to improve medication intake behavior.
Practice implications: This study could serve as a guide for the development of other health interventions.
Keywords: Adherence, self-efficacy, patient empowerment, eHealth, technology-mediated, interpersonal communication, development, intervention, medical research council’s framework, beliefs about medication

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